Dundee Waterfront said construction will begin on the £45m V&A Museum, the £14m Dundee Railway Station and £30m Riverside flats development.
The £32m Olympia Swimming Pool and new £8m Malmaison Hotel are expected to be completed.
To date, nearly £500m has been committed to the Waterfront project.
2013 will also see the demolition of Tayside House, the Hilton Hotel and the Gala Casino.
Refurbishment work will be carried out on the Tay Road Bridge, while the Station Bridge and South Marketgait Bridge will be replaced.
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9,000 new jobs are expected to be created as a result of the investment.
Mike Galloway, Dundee's director of city development, said: "We are very pleased with the rate of progress and the interest that is being generated in Dundee Waterfront.
"We are delighted with the amount of investment being generated by local businesses and, increasingly, by inward investment.
"2013 is set to be a watershed year as we close in on £500m of committed investment, or half the overall target of £1bn."
Allan McQuade, business infrastructure director for Scottish Enterprise, said: "The Dundee Waterfront Project has a pivotal role to play in helping the City of Dundee stimulate economic growth both for Tayside and the wider Scottish economy.
"This significant level of investment will help transform the Waterfront area through major infrastructure improvements that will deliver economic benefits both today and in the future.
"The progress to date has been very encouraging and 2013 promises to be an exciting year as the vision for the Waterfront continues to emerge along the banks of the Tay."
(IT/GK)
