A diversion route will be signposted via the A1 southbound to Oaktree Junction, returning to exit the A1 at Gladsmuir Junction via the northbound off-slip.
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Emergency services and other relevant stakeholders have been consulted in advance to make them aware of the plans.
Tommy Deans, BEAR Scotland's South East Network Manager, said: "It is essential that we close the slip road during these works to ensure the safety of road workers and motorists.
"We thank motorists and the local community in advance for their understanding."
